当前位置:首页 师资队伍 教授及主任医师 基础医学系(按拼音排序)
刘伟,1987年毕业于第四军医大学空军医学系,1998年于日本名古屋大学医学部获医学博士学位,1998至1999年在名古屋大学从事博士后研究(合作导师 中岛 泉),1999年至2001年任日本爱知医科大学药理学系助理教授,主要从事肿瘤细胞信号转导和细胞凋亡方面研究。2001年至2007年在美国国家卫生研究院(NICHD,NIH)开展了细胞内囊泡运输和高尔基体结构及功能研究 (合作导师 Jennifer Lippincott-Schwartz)。2007年受聘mgm美高梅79906,建立了以细胞器结构和功能为中心研究的细胞器生物学实验室。目前的主要研究方向是自噬的分子细胞学机制和功能。迄今共发表研究论文60余篇,被引用超过6000次。研究得到国家自然科学基金重大项目、重点项目和国家重点研发计划项目的资助。现任我校求是特聘教授,mgm美高梅79906生物化学系主任,中国生物物理学会膜生物学分会副会长,中国细胞生物学学会细胞器分会副会长。
主要学术兼职
Autophagy 杂志副主编
Journal of Molecular Cell Biology杂志编委
在研项目
1. 国家自然基金重大项目:PI3P介导自噬前体形成和生长延伸的分子机制研究。
2. 国家重点研发计划项目:多细胞生物中自噬启动蛋白质机器的修饰和调控机制。
3. 国家自然基金面上项目:自噬体形成中Atg4B和LC3与自噬膜动态作用及调控。
4. 国家自然基金重点项目:自噬蛋白乙酰化修饰在自噬膜泡形成中的功能和调控。
近期论文
Yu H, Yang F, Dong P, Liao S, Liu WR, Zhao D, Qin B, Dou Z, Liu Z, Liu W, Zang J, Lippincott-Schwartz J, Liu X, Yao X (2019) NDP52 tunes cortical actin interaction with astral microtubules for accurate spindle orientation. Cell Res 29 (8):666-679.
Cheng X, Max, Zhu Q, Song D, Ding X, Li L, Jiang X, Wang X, Tian R, Su H, Shen Z, Chen S, Liu T, Gong W, Liu W, Sun Q (2019) Pacer is a mediator of mTORC1 and GSK3-TIP60 signaling in regulation of autophagosome maturation and lipid metabolism. Mol Cell 73(4):788-802.
You Z, Xu Y, Wan W, Zhou L, Zhou T, Shi Y, Liu W (2019) TP53INP2 contributes to autophagosome formation by promoting LC3-ATG7 interaction.Autophagy 15(8):1309-1321.
Wan W and Liu W (2019) MTORC1 regulates autophagic membrane growth by targeting WIPI2. Autophagy 15(4):742-743.
Zhou W, Liu Y, Lis, Guo, Sun Q, Jin J, Rao X, Li M, Sun M, Jiang M, Xu Y, Teng L, Jin Y, Si J, Liu W, Kang L, Zhou T (2018) Long noncoding RNA GMAN, upregulated in gastric cancer tissues, is associated with metastasis in patients and promotes translation of Ephrin A1 by competitively binding GMAN-AS. Gastroenterology 156(3):676-691.
Wan W, You Z, Zhou L, Xu Y, Peng C, Zhou T, Yi C, Shi Y, Liu W (2018) mTORC1-regulated and HUWE1-mediated WIPI2 degradation controls autophagy flux. Mol Cell 72:303-315.
Su H, Liu W (2018) PI3KC3/VPS34 control by acetylation. Autophagy 14:1086-1087.
Wan W, You Z, Xu Y, Zhou L, Guan Z, Peng C, Wong CC, Su H, Zhou T, Xia H, Liu W (2017) mTORC1 phosphorylates acetyltransferase p300 to regulate autophagy and lipogenesis. Mol Cell 68:323-335.
Su H, Yang F, Wang T, Shen Q, Huang J, Peng C, Zhang Y, Wan W, Wong CC, Sun Q, Wang F, Zhou T, Liu W (2017) VPS34 acetylation controls its lipid kinase activity and the initiation of canonical and non-canonical autophagy. Mol Cell 67:907-921.
Lu Y, Xie S, Zhang W, Zhang C, Gao C, Sun Q, Cai Y, Xu Z, Xiao M, Xu Y, Huang X, Wu X, Liu W, Wang F, Kang Y, Zhou T (2017) Twa1/Gid8 is a b-caterin nuclear retention factor in Wnt signaling and colorectal tumorigenesis. Cell Res 27:1422-1440.
Cheng X, Ma X, Ding X, Li L, Jiang X, Shen Z, Chen S, Liu W, Gong W, Sun Q (2017) Pacer mediates the function of class III PI3K and HOPS complexs in autophagosome maturation by engaging Stx17. Mol Cell 65:1029-1043.
Wang H, An P, Xie E, Wu Q, Fang X, Gao H, Zhang Z, Li Y, Wang X, Zhang J, Li G, Yang L, Liu W, Min J, Wang F (2017) Characterization of ferroptosis in murine models of hemochromatosis. Hepatology 66:449-465.
Xu Y, Wan W, Shou X, Huang R, You Z, Shou Y, Wang L Zhou T, Liu W (2016) DOR/TP53INP2, a mediator of cell autophagy, promotes rDNA transcription via facilitating the assembly of polymerase I pre-initiation complex at rDNA promoter. Autophagy 12:1118-1128.
Zhang C, Zhang W, Lu Y, Yan X, Yan X, Zhu X, Liu W, Yang Y, Zhou T (2015) NudC regulates actin dynamics and ciliogenesis by stabolizing cofilin 1. Cell Res 26:239-253.
Huang R, Liu W (2015) Identifying an essential role of nuclear LC3 for autophagy. Autophagy 11:852-853.
Chang C, Su H, Zhang D, Wang Y, Shen Q, Liu B, Huang R, Zhou T, Peng C, Wong CC, Shen HM, Lippincott-Schwartz J, Liu W (2015) AMPK-dependent phosphorylation of GAPDH triggers Sirt1 activation and is necessary for autophagy upon glucose starvation. Mol Cell 60:930-940.
Huang R, Xu Y, Qian J, Wan W, Liu B, Chang C, Zhou T, Lippincott-Schwartz J, Liu W (2015) Deacetylation of nuclear LC3 drives autophagy initiation under starvation. Mol Cell 57:456-466.
Feng WF, Chang CM, Luo DJ, Su H, Yu SS, Hua W, Chen ZH, Hu H, Liu W (2014) Dissection of autophagy in human platelets. Autophagy 10:642-651.
Liu B, Fang MD, Hu Y, Huang BS, Li N, Chang CM,Huang R,Xu X, Yang ZG, Chen Z, Liu W (2014) Hepatitis B virus X protein inhibits autophagic degradation by impairing lysosomal maturation. Autophagy 10:416-430.
Li N, Zhang L, Chen L, Feng W, Xu Y, Chen F, Liu X, Chen Z, Liu W (2012) MxA inhibits hepatitis B virus replication by interaction with core protein HBcAg. Hepatology 56:803-811.
Xiang WQ, Feng WF, Ke W, Sun Z, Chen Z, Liu W (2011) Hepatitis B virus X protein stimulates IL-6 expression in hepatocytes via a MyD88-dependent pathway. J Hepatol 54:26-33.